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Edexcel A-Level Biology: The Cell Cycle & Reproduction

0:00 / 5:45
Interphase: preparation
0:00 - 0:42

G1, S and G2 — DNA replication to 4n, organelle synthesis, growth, and centriole prep for spindle formation.

Prophase to metaphase
0:42 - 1:20

Chromosomes condense, the nuclear envelope breaks down, centrioles reach the poles, then chromatid pairs align on the equator.

Anaphase to plant cytokinesis
1:20 - 1:58

Centromeres split, spindles pull identical chromatids apart, nuclear envelopes reform, and a cell plate partitions plant daughters.

Mitotic index & staining
1:58 - 2:32

Index = (cells in mitosis ÷ total) × 100; stains make chromosomes and spindles visible so phases can be counted.

Magnification maths
2:32 - 3:05

Measure, convert units (mm oµm), divide image by actual size, and round to two significant figures.

Meiosis: variation & errors
3:05 - 3:44

Crossing over, independent assortment, linked genes, and non-disjunction in anaphase II causing abnormal zygote ploidy.

Double fertilisation
3:44 - 4:24

Tube and generative nuclei, then zygote (2n) plus triploid endosperm (3n) — the dual fusion unique to flowering plants.

Cancer & cell-cycle control
4:24 - 5:03

DNA methylation silences tumour suppressors like RB; Paclitaxel blocks spindle shortening and slows tumour growth.

Pollination & hybrid barriers
5:03 - 5:45

Cross vs self-pollination trade-offs, and why mismatched hybrid chromosomes cannot pair in meiosis.