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Haloperidol Pharmacology and Clinical Management
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Haloperidol Pharmacology and Clinical Management
Haloperidol Pharmacology and Clinical Management
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1
Question
What is the drug class of Haloperidol?
Page 1
Answer
First-generation (typical) antipsychotic of high potency.
2
Question
What is the mechanism of action for Haloperidol?
Page 1
Answer
Blocks dopamine D2 receptors and decreases psychosis.
3
Question
What are the FDA indications for Haloperidol?
Page 1
Answer
Schizophrenia, Tourette’s disorder, severe agitation, acute psychosis.
4
Question
What routes of administration are available for Haloperidol?
Page 1
Answer
PO, IM short-acting, IM decanoate long-acting.
5
Question
What is the half-life of oral Haloperidol?
Page 1
Answer
14-26 hours.
6
Question
What is the half-life of Haloperidol decanoate?
Page 1
Answer
~3 weeks.
7
Question
What is the major side effect of Haloperidol?
Page 1
Answer
Extrapyramidal symptoms (EPS).
8
Question
What are the types of extrapyramidal symptoms from Haloperidol?
Page 2
Answer
Dystonia, akathisia, parkinsonism, tardive dyskinesia.
9
Question
What symptoms characterize acute dystonia from Haloperidol?
Page 2
Answer
Neck spasms, tongue protrusion, oculogyric crisis, jaw stiffness.
10
Question
What are symptoms of akathisia associated with Haloperidol?
Page 2
Answer
Restlessness, pacing, anxiety, can’t sit still.
11
Question
What symptoms define parkinsonism from Haloperidol?
Page 2
Answer
Tremor, rigidity, shuffling gait, masked face.
12
Question
What features describe tardive dyskinesia from Haloperidol?
Page 3
Answer
Lip smacking, tongue movements, facial grimacing, often irreversible.
13
Question
What treatments are used for EPS caused by Haloperidol?
Page 3
Answer
Benztropine, diphenhydramine, reduce dose, switch medication.
14
Question
What is the life-threatening reaction associated with Haloperidol?
Page 3
Answer
Neuroleptic malignant syndrome (NMS).
15
Question
What are symptoms of neuroleptic malignant syndrome from Haloperidol?
Page 3
Answer
Fever, rigidity, confusion, elevated CK, autonomic instability.
16
Question
What tool monitors tardive dyskinesia in Haloperidol patients?
Page 3
Answer
AIMS scale.
17
Question
What cardiac risk does Haloperidol pose?
Page 4
Answer
QT prolongation leading to torsades risk.
18
Question
What are contraindications for Haloperidol?
Page 4
Answer
Parkinson’s disease, QT prolongation, severe CNS depression, coma.
19
Question
What considerations apply for elderly Haloperidol patients?
Page 4
Answer
Start low dose, increased EPS risk, increased mortality in dementia.
20
Question
What is the dosing interval for IM Haloperidol decanoate?
Page 4
Answer
Every 4 weeks.
21
Question
What characterizes high potency antipsychotics like Haloperidol?
Page 4
Answer
High EPS, low sedation, minimal anticholinergic effects.
22
Question
What drug interactions increase risks with Haloperidol?
Page 5
Answer
Methadone and SSRIs cause QT prolongation; metoclopramide increases EPS.
23
Question
What patient education points apply to Haloperidol use?
Page 5
Answer
Report stiffness, avoid alcohol, don’t stop abruptly, report restlessness.
24
Question
What labs and monitoring are recommended for Haloperidol?
Page 5
Answer
EKG, AIMS, CMP, CBC.
25
Question
What are overdose symptoms of Haloperidol?
Page 5
Answer
Severe EPS, hypotension, respiratory depression, QT prolongation.
26
Question
What does the HALDOL mnemonic represent for Haloperidol?
Page 6
Answer
H-High potency, A-Akathisia, L-Long acting, D-Dopamine blocker, O-Orthostatic hypotension, L-Long QT.
27
Question
According to HALDOL mnemonic, what does H stand for?
Page 6
Answer
High potency.
28
Question
What does A represent in the HALDOL mnemonic?
Page 6
Answer
Akathisia.
29
Question
What distinguishes neck spasms in EPS from Haloperidol?
Page 2
Answer
Part of acute dystonia.
30
Question
How does tongue protrusion relate to Haloperidol side effects?
Page 2
Answer
Symptom of acute dystonia.