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Chemotherapy Agents and Nursing Care
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Chemotherapy Agents and Nursing Care
Chemotherapy Agents and Nursing Care
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1
Question
Name two antibiotics used in cancer therapy that interfere with DNA or RNA synthesis.
Answer
Bleomycin; Doxorubicin
2
Question
What is a key property of nitrosoureas in chemotherapy?
Answer
Cross the blood-brain barrier
3
Question
What is the role of hormonal agents in cancer therapy?
Answer
Bind to hormone receptors to alter cellular growth
4
Question
What is the function of monoclonal antibodies in cancer treatment?
Answer
Destroy cancer cells while sparing normal cells
5
Question
What is the cell cycle phase where DNA synthesis occurs?
Answer
S phase
6
Question
Which phase is the pre-mitotic stage of the cell cycle?
Answer
G2 phase
7
Question
What characterizes cell cycle-specific (CCS) drugs?
Answer
Therapeutic effect in a specific phase only
8
Question
Name an anti-metabolite used in chemotherapy.
Answer
Methotrexate
9
Question
List one anti-metabolite example besides Methotrexate.
Answer
6-mercaptopurine
10
Question
What is the action of anti-metabolites in cancer treatment?
Answer
Block enzymes needed for DNA synthesis
11
Question
Give an example of a topoisomerase inhibitor used in cancer therapy.
Answer
Irinotecan (Camptosar)
12
Question
What is the general action of topoisomerase inhibitors?
Answer
Block enzymes needed for DNA synthesis
13
Question
What do mitotic inhibitors generally do in cancer therapy?
Answer
Arrest metaphase by inhibiting mitotic spindle formation
14
Question
Name a mitotic inhibitor listed in the text.
Answer
Vincristine
15
Question
What is a defining feature of cell cycle non-specific (CCNS) drugs?
Answer
Therapeutic effect affects all phases of the cell cycle
16
Question
What class of drugs breaks DNA helix to interfere with replication?
Answer
Alkylating agents
17
Question
Provide an example of an alkylating agent.
Answer
Cisplatin
18
Question
What is the function of antibiotics (-cin) in chemotherapy?
Answer
Interfere with DNA synthesis and prevent RNA synthesis
19
Question
Name an antibiotic used in chemotherapy.
Answer
Doxorubicin
20
Question
What type of drug crosses the blood-brain barrier and is an example of nitrosoureas?
Answer
Carmustine
21
Question
What is the role of hormonal agents in cancer therapy?
Answer
Bind to hormone receptors or block hormone binding to affect growth
22
Question
What is an example of a monoclonal antibody used in cancer treatment?
Answer
Rituximab
23
Question
Name a monoclonal antibody listed in the text besides Rituximab.
Answer
Trastuzumab
24
Question
What are two routes of administering chemotherapy mentioned in the document?
Answer
Oral and IV (intravenous)
25
Question
What special administration route is used for intrathecal chemotherapy?
Answer
Intrathecal (Ommaya reservoir)
26
Question
What is a key safety precaution when preparing chemotherapy drugs?
Answer
Work in a well-ventilated area and wear PPE (gloves, gown, face shield)
27
Question
Why is hand hygiene important in chemotherapy preparation?
Answer
To prevent contamination and infection during handling
28
Question
What is stomatitis and how is xerostomia defined in nursing care?
Answer
Stomatitis: mouth sores; xerostomia: dry mouth.
29
Question
List two dietary/comfort measures for stomatitis management.
Answer
Soft bland diet; ice chips/popsicles.
30
Question
What oral care practice should be avoided in stomatitis patients?
Answer
Alcohol-based mouthwash.