Organic Medicinal Chemistry

Upload a PDF by clicking the button below 👇

View

Untitled Deck

Study

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

SAR: 1. DQWLEDFWHULDODFWLYLWXSWRRQO, 2. QRQSRODUZDWHUVROXELOLWDQWLEDFWHULDODFWLYLW, 3. Branching decreases antibacterial property except isopropyl alcohol - more potent, cheaper, less toxic. 60% EtOH, 40% Isopropyl Alcohol, 4. Isomeric alcohol potency decreases in the order: Primary, Secondary, Tertiary, MOA: Protein denaturation/precipitation, Alcohol USP - ethanol, grain alcohol, wine spirit, cologne spirit, spiritus vini rectificatus - most widely abused of all recreational drugs, commercial ethanol. Manufactured by: Fermentation of grains and other CHOs, Hydration of ethene. Metabolism: Ethanol to Acetaldehyde - Enzyme: alcohol dehydrogenase; Acetaldehyde to Acetic acid - Enzyme: aldehyde dehydrogenase, DRUGS THAT INTERFERE WITH ALCOHOL METABOLISM: a. Fomepizole - Inhibits alcohol dehydrogenase, Used as an antidote for methanol poisoning, b. Disulfiram - used as a deterrent for alcohol addiction, inhibits aldehyde dehydrogenase, accumulation of aldehyde, extreme hangover-like symptoms, nausea, vomiting, vasodilatory flushing, Types of Alcohols: Absolute alcohol - 95% alcohol, Dehydrated alcohol - 99% alcohol prepared by azeotropic distillation, Diluted alcohol - 49-50% alcohol, Denatured alcohol - EtOH rendered unfit for use in beverages by the addition of substances, Completely denatured alcohol contains added wood alcohol and benzene, unsuitable for internal or external use.

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Untitled Deck

Study

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

1. DQWLEDFWHULDODFWLYLWXSWRRQO
2. QRQSRODUZDWHUVROXELOLWDQWLEDFWHULDODFWLYLW
3. Branching decreases antibacterial property except isopropyl alcohol:
- more potent
- cheaper
- less toxic (60% EtOH, 40% Isopropyl Alcohol)
4. Isomeric alcohol potency decreases in the order: Primary > Secondary > Tertiary
MOA: Protein denaturation/precipitation
1. Alcohol USP (ethanol, grain alcohol, wine spirit, cologne spirit, spiritus vini rectificatus): most widely abused of all recreational drugs
- Manufactured by fermentation of grains and other CHOs
- Metabolism: Ethanol to Acetaldehyde (Enzyme: alcohol dehydrogenase), Acetaldehyde to Acetic acid (Enzyme: aldehyde dehydrogenase)
DRUGS THAT INTERFERE WITH ALCOHOL METABOLISM:
- Fomepizole: inhibits alcohol dehydrogenase, used as an antidote for methanol poisoning
- Disulfiram: used as a deterrent for alcohol addiction, inhibits aldehyde dehydrogenase, accumulation of aldehyde, extreme hangover-like symptoms, nausea, vomiting, vasodilatory flushing
Types of Alcohols:
- Absolute alcohol (95% alcohol)
- Dehydrated alcohol (99% alcohol, prepared by azeotropic distillation)
- Diluted alcohol (49-50% alcohol)
- Denatured alcohol: EtOH rendered unfit for use in beverages by the addition of substances, completely denatured alcohol contains added wood alcohol and benzene, unsuitable for internal or external use

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer

Question

Answer